2’-Hydroxyacetophenone-13C2

Chemical Name:2’-Hydroxyacetophenone-13C2
Synonyms:1-(2-Hydroxyphenyl)ethan-1-one-1,2-13C2
Molecular Formula:C₆¹³C₂H₈O₂
Molecular Weight:138.13
Category:Building Blocks; Isotopic Labeled Analogues;
Applications:2’-Hydroxyacetophenone-13C2 is an intermediate in the synthesis of Zonisamide-13C2-15N (Z700003), the labeled analogue of Zonisamide (Z700000), a sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant.
References:Masuda, Y., et al.: Arzneim.-Forsch., 30, 477 (1980); Hammond, E.J., et al.: Gen. Pharmacol., 18, 303 (1987); Schmidt, D., et al.: Epilepsy Res., 15, 67 (1993); Sorkin, E.M., et al.: Drugs, 45, 760 (1993)
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