N-(9-Hydroxy-9H-fluoren-2-yl)-acetamide

Chemical Name:N-(9-Hydroxy-9H-fluoren-2-yl)-acetamide
Synonyms:N-9-Hydroxyfluoren-2-yl-acetamide; 2-Acetylamino-9-fluorenol; 9-Hydroxy-2-acetylaminofluorene; 9-Hydroxy-N-2-fluorenylacetamide; NSC 12397;
CAS Number:57229-41-1
Molecular Formula:C₁₅H₁₃NO₂
Molecular Weight:239.27
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-(9-Hydroxy-9H-fluoren-2-yl)-acetamide is a liver produced metabolite of the cancinogens 2-acetamidofluorene (A158535), which can be activated by liver homogenate and formed potent frameshift mutagens. It is used to study the mechanism of liver carcinogenesis and as a reference material during its identification or quantitation.
References:Ames, B., et al.: Proc. Nat. Acad. Sci. U. S.A., 70, 2281 (1973); Verna, L., et al.: Pharmacol. Ther., 71, 83 (1996)
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