Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt

Chemical Name:Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt
Synonyms:N-(Hydroxyphenoxyphosphinyl)-L-alanine 1-Methylethyl Ester Sodium Salt; (2S)-Isopropyl 2-((Hydroxy(phenoxy)phosphoryl)amino)propanoate Sodium Salt
Alternate CAS #:free acid: 1520010-86-9
Molecular Formula:C₁₂H₁₇NNaO₅P
Molecular Weight:309.23
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Isopropyl N-(Hydroxyphenoxyphosphinyl)alaninate Sodium Salt is an impurity of Sofosbuvir (P839640), a prodrug that is metabolized to the active antiviral agent 2′-deoxy-2′-α-fluoro-β-C-methyluridine-5′-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled PSI-7977 as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References:Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010);
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