Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate-d4

Chemical Name:Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate-d4
Synonyms:Isopropyl (4-((2-(Methylcarbamoyl)pyridin-4-yl)oxy)phenyl)carbamate-d4;
Molecular Formula:C₁₇H₁₂D₇N₃O₄
Molecular Weight:336.39
Category:Building Blocks; Isotopic Labeled Analogues;
Applications:Isotope labelled Isopropyl 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]phenylcarbamate is an impurity in the synthesis of Sorafenib (S676850), a multiple kinase inhibitor targeting both RAF kinase and receptor tyrosine kinases that promote angiogensis. Antineoplastic.
References:Richly, H., et al.: Int. J. Clin. Pharmacol. Ther., 41, 620 (2003), Khire, U.R., et al.: Bioorg. Med. Chem. Lett., 14, 783 (2004), Wilhelm, S.M., et al.: Cancer Res., 64, 7099 (2004), Rini, B.I., et al.: Expert Opin. Pharmacother., 7, 453 (2006),
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