J 147

Chemical Name:J 147
Synonyms:2,2,2-Trifluoroacetic Acid 1-(2,4-Dimethylphenyl)-2-[(3-methoxyphenyl)methylene]hydrazide;
CAS Number:1146963-51-0
Molecular Formula:C₁₈H₁₇F₃N₂O₂
Molecular Weight:350.33
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:J 147 is a novel neurotrophic drug for cognitive enhancement and Alzheimer’s disease. J 147 is an exceptionally potent, orally active and broadly neuroprotective compound has the ability to enhance memory in normal animals as well as to prevent memory deficits in Alzheimer’s disease (AD) transgenic mice. The neurotrophic and memory-enhancing activities of J147 are associated with an increase in brain derived neurotrophic factor (BDNF) levels and the expression of BDNF responsive proteins, the enhancement of LTP, the preservation of synaptic protein, the reduction of amyloid plaques.
References:Chen, J., et al.: J. Neurosci., 25, 2366 (2005), Maher, P., et al.: Brain Res., 1173, 117 (2007), Liu, Y., et al.: J. Neurochem., 105, 1336 (2008), Herrup, K., et al.: J. Neurosci., 30, 16755 (2010);
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