CAS:1975217-09-4|2-Chlorophenol – 13C6

Catalogue Number:C360552
Chemical Name:2-Chlorophenol – 13C6
CAS Number:1975217-09-4
Alternate CAS #
95-57-8
Molecular Formula:¹³C₆H₅ClO
Molecular Weight:134.51
Category:Building Blocks; Isotopic Labeled Analogues;
Applications:2-Chlorophenol is an intermediate used in the synthesis of Diclofenamide-13C6 (D436532), which is a labeled Diclofenamide, a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP).
References:Brzozowski, Z. et al.: Eur. J. Med. Chem., 46, 3656 (2010); Tawil, R. et al.: Ann. Neurol., 47, 46 (2000); Casey, J. et al.: J. Med. Chem., 47, 2337 (2004);
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