CAS:565452-98-4|(2R)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile

Catalogue Number:C363785
Chemical Name:(2R)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile
Synonyms:(2R)-1-(2-Chloroacetyl)-2-pyrrolidinecarbonitrile; Vildagliptin Chloroacetyl Nitrile (R)-Isomer
CAS Number:565452-98-4
Molecular Formula:C₇H₉ClN₂O
Appearance:White to Pale Yellow Solid
Melting Point:64-67°C
Molecular Weight:172.61
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(2R)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile, can be used in the synthesis of 1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine, and Vildagliptin (C363780), which are potent, selective, and orally bioavailable dipeptidyl peptidase IV Inhibitor with Antihyperglycemic properties, that might be used for the treatment of type 2 diabetes.
References:Singh, S.K., et al.: Beil. J. Org. Chem., 4, 20 (2008); Villhauer, E. B., et al.: J. Med. Chem., 46, 2774 (2003);
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