Catalogue Number:C366253
Chemical Name:2-Chlorotetrahydro-2-oxo-2H-1,3,2-oxazaphosphorin
Synonyms:2-Chloro-1,3,2-oxazaphosphacyclohexane 2-Oxide
CAS Number:5638-58-4
Molecular Formula:C₃H₇ClNO₂P
Molecular Weight:155.52
Category:Building Blocks; Miscellaneous;
Applications:2-Chlorotetrahydro-2-oxo-2H-1,3,2-oxazaphosphorin is an intermediate in the synthesis of N-Dides(2-chloroethyl) N-(2-Hydroxyethyl),N-(2-ethoxyethyl) Cyclophosphamide (C984610) which is a derivative of Cyclophosphamide Monohydrate (C988580), a known human carcinogen that is widely used in cancer chemotherapy because it can cross-link DNA causing strand breakage and mutation.
References:Wheeler, A.G., et al.: Toxicol. Appl. Pharmacol., 4, 324 (1962), Fraiser, L.H., et al.: Drugs, 42, 781 (1991), Colvin, O.M., et al.: Curr. Pharmaceut. Design, 5, 555 (1999)
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Posted inMaterials
CAS:5638-58-4|2-Chlorotetrahydro-2-oxo-2H-1,3,2-oxazaphosphorin
