CAS:314771-88-5|(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine

Catalogue Number:C367720
Chemical Name:(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine
CAS Number:314771-88-5
Molecular Formula:C₁₈H₁₄ClFN₄O₄
Molecular Weight:404.78
Category:Building Blocks;
Applications:(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib (A355305) which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
References:Zhang, X., et al.: Bioorg. Med. Chem., 21, 7988 (2013); Ermoli, A. et al.: J. Med. Chem., 52, 4380 (2009); Pearson, S. et al.: Synthesis, 15, 2503 (2005);
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