CAS:6340-55-2|2-Chloro-6-methoxy-4-methylquinoline

Catalogue Number:C370060
Chemical Name:2-Chloro-6-methoxy-4-methylquinoline
Synonyms:2-Chloro-4-methyl-6-methoxyquinoline; NSC 13577; NSC 51245; 2-hloro-6-methoxy-lepidine
CAS Number:6340-55-2
Molecular Formula:C₁₁H₁₀ClNO
Appearance:Grey Solid
Molecular Weight:207.66
Storage:20°C
Solubility:Chloroform, Dichloromethane
Category:Building Blocks; Miscellaneous;
Applications:2-Chloro-6-methoxy-4-methylquinoline is an intermediate in the synthesis of Tafenoquine-d3 Succinate which is the labelled analog of Tatenoquine (T004760), a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.
References:McIntyre, J. A., et al.: Drugs. Future., 28, 859 (2003); LaMontagne, M.P., et al.: J. Medn. Chem., 32, 1728 (1989);
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