The development of nanoscale delivery vehicles based on polymeric micelles has attracted attention in the diagnostic and therapeotic applications in biomedicine. To construct a micellar magnetic resonance imaging (MRI) contrast agent (CA) with biocompatibility and targeting specificity, researchers synthesized two types of amphiphilic diblock polymers, mPEG-PG(DOTA(Gd))-b-PCL and FA-PEG-b-PCL, to form mixed micelles by coassembly. Consisting of poly(caprolactone) […]
What Effects the Chlorosulfolipids in Ochromonas Danica Have on Lipid Bilayers
Found in the freshwater microalga Ochromonas danica, the amphiphilic chlorosulfolipids are very unique due to their high levels of chlorination and sulfation. The major chlorosulfolipid found in O. danica is danicalipin A which contains six chlorination and two sulfates with certain stereochemistry on a linear 22-carbon chain. It is difficult to purify danicalipin A from natural resources, so there […]
The Activation of Mitochondria Apoptosis Pathway for Cancer Therapy by Co-develiery of siRNA and Lonidamine
As there are cell-suicide weapons existing in mitochondria, the mitochondria-mediated apoptosis pathway is an effective option for cancer therapy. However, the efficacy of this kind of chemotherapy are greatly reduced due to the apoptosis evading of cancer cells allowed by the anti-apoptotic proteins that are over-expressed in the mitochondria of many malignant tumors, such as […]
The Exploration of Cyclopropane Modifications by Ultraviolet Photodissociation Mass Spectrometry
Normally, the structural analysis of complex lipids relies on tandem mass spectrometry (MS/MS) or the activation methods based on collision, such as collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD). In the previous, these methods were not been used to explore the subtle characteristics of glycerophospholipids, such as sn-stereochemistry and unsaturation elements, including cyclopropane modification […]
The Multifunctional Nanocomposite of Poly(l-Lactide) and Polyethylene Glycol-Grafted GQDs for Enhanced Therapeutics and Molecule Analysis
Due to the large surface area and excellent mechanical flexibility, Photoluminescent (PL) graphene quantum dots (GQDs) with fascinating optical and electronic properties have promising applications in biomedical engineering. In order to enhance the therapeutic efficiency, the research team proposed a multifunctional nanocomposite of poly(l-lactide) (PLA) and polyethylene glycol (PEG)-grafted GQDs (f-GQDs) used for the analysis of intracellular […]
Mitomycin C and Methotrexate Loaded DSPE-PEG Micelles: A Key Factor for Nanoscale Drug Delivery System
The design of nanoscale drug delivery systems used for the targeted co-delivery of multiple therapeutic drugs still remains a challenge. However, researchers prepared mitomycin C (MMC) and methotrexate (MTX) loaded DSPE-PEG micelles (MTX-M-MMC) by self-assembly using the dialysis technique, and the MMC-soybean phosphatidylcholine complex was encapsulated in the MTX-functionalized DSPE-PEG micelles. The experiment suggested that MTX-M-MMC coordinate the early […]
The Roles the Diverse Phosphatidic Acid Species Play on Exocytoses
Phosphatidic Acid (PA) has aroused people’s interests due to its role in diverse key biological functions, including its being an intermediate in the synthesis of all membrane glycerophospholipids, a participant of membrane biogenesis, a necessary signaling molecule in cell proliferation and cytoskeletal rearrangement, as well as a participant in endocrine, neuroendocrine exocytosis and synaptic neurotransmission. Mammals can have more than […]
The Effect of PZLY on Hierarchy and Mechanics in Peptide-Polymer Hybirds
By combining the hierarchy of biological species with synthetic concepts, peptide-polymer hybrids can control the molecular design and material properties. By further incorporating covalent cross links, the molecular complexity is enhanced so that both a physical and covalent network is allowed. Through the process, both the structure and function of polyethylene glycol (PEG)-network hybrids are regulated by […]
The Application of RGD@Micelles on Gastric Cancer Therapy
The polymer-drug conjugate with controlled drug release, such as arginine-glycine-aspartic acid (RGD)-decorated polyethylene glycol (PEG)-paclitaxel (PTX) conjugates containing disulfide linkage, can be used for gastric cancer therapy. The amphiphilic PEG-PTX conjugates can assemble into micelles, RGD@Micelles, and then decompose under the reduction of glutathione (GSH) and finally release PTX in weakly acidic conditions in intracellular environment. The […]
Fluorescent Labeling Nanomedicine – A Promising System Used for Human Therapuetics
Nanomedicine is one of the most popular topics in disease diagnostics, prevention and treatment. Lipids, such as liposomes and solid lipid nanoparticles (SLNPs), are widely used in nanosystems, and these nanosystems are used for a variety of therapeutic fields, such as anticancer therapies, antimicrobials, treatment of central nervous system diseases and other conditions. By loading […]