Systemic antibiotic therapy is the major therapeutic method for acute bacterial rhinosinusitis (ABRS). However, this kind of therapy often gives rise to the side effects, such as dizziness, diarrhea and drug resistance. In order to avoid the side effects and achieve sustained release of drugs, researchers developed a new polyethylene glycol hydrogel (PEG-H) treatment model. […]
The Prevention of Bone Infections By Immobilizing Antibiotic-Loaded Polymeric Coatings on Orthopaedic Implants
In orthopaedic surgeries, the implant-associated infections are extremely critical as they may hinder bone healing, resulting in implant failure and even osteomyelitis. Used for local delivery of antibiotics at surgical sites, drug-eluting implants are considered to be a promising tool in infection prevention. The antibiotic vancomycin was encapsulated in a polyethylene glycol (PEG)-based hydrogel film which […]
The Promise of PEI (Polyetherimide) in Drug Delivery
Definition PEI (Polyetherimide) is an amorphous amber-to-transparent engineering thermoplastic. The molecular formula of PEI is C37H24O6N2. Owing to its high temperature resistance and tensile strength, dimensional stability, excellent flame resistance and low smoke emission, PEI has been an ideal material used in the automotive, electrical, medical and other industrial fields. It is also a promising […]
The Potential of the Poly(glycerol) Used for Mixed Micelles for Tumor-Targeted Imaging
The development of nanoscale delivery vehicles based on polymeric micelles has attracted attention in the diagnostic and therapeotic applications in biomedicine. To construct a micellar magnetic resonance imaging (MRI) contrast agent (CA) with biocompatibility and targeting specificity, researchers synthesized two types of amphiphilic diblock polymers, mPEG-PG(DOTA(Gd))-b-PCL and FA-PEG-b-PCL, to form mixed micelles by coassembly. Consisting of poly(caprolactone) […]
1-palmitoyl-2-oleoyl-glycero-3-phosphocholine (POPC)
POPC (1-palmitoyl-2-oleoyl-glycero-3-phosphocholine), a phospholipid with 16:0 and 18:1 acyl chains, can be used for the study of the lipid bilayer properties and other related biophysical experiments with phospholipids. POPC has been considered one of the model lipids for biophysical experiments, and it is also an excellent synthetic substitute for EPC since the major constituent in Egg PC is 1-palmitoyl-2-oleoyl PC. In addition, POPC can […]
What Effects the Chlorosulfolipids in Ochromonas Danica Have on Lipid Bilayers
Found in the freshwater microalga Ochromonas danica, the amphiphilic chlorosulfolipids are very unique due to their high levels of chlorination and sulfation. The major chlorosulfolipid found in O. danica is danicalipin A which contains six chlorination and two sulfates with certain stereochemistry on a linear 22-carbon chain. It is difficult to purify danicalipin A from natural resources, so there […]
The Activation of Mitochondria Apoptosis Pathway for Cancer Therapy by Co-develiery of siRNA and Lonidamine
As there are cell-suicide weapons existing in mitochondria, the mitochondria-mediated apoptosis pathway is an effective option for cancer therapy. However, the efficacy of this kind of chemotherapy are greatly reduced due to the apoptosis evading of cancer cells allowed by the anti-apoptotic proteins that are over-expressed in the mitochondria of many malignant tumors, such as […]
The Exploration of Cyclopropane Modifications by Ultraviolet Photodissociation Mass Spectrometry
Normally, the structural analysis of complex lipids relies on tandem mass spectrometry (MS/MS) or the activation methods based on collision, such as collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD). In the previous, these methods were not been used to explore the subtle characteristics of glycerophospholipids, such as sn-stereochemistry and unsaturation elements, including cyclopropane modification […]
PAMAM (Poly(amidoamine)) Dendrimer: A Promising Tool in Drug Delivery
Definition PAMAM (Poly(amidoamine)), a class of dendrimer with spherical shape composed of repeatedly branched subunits of amide and amine functionality, is characterized by an internal molecular structure of tree-like branches, with each outward layer containing exponentially more branching points. PAMAM has good molecular uniformity, narrow distribution of molecular weight, defined size and shape characteristics, as well as a multifunctional […]
1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)
DOPC (1,2-Dioleoyl-sn-glycero-3-phosphocholine), a kind of phosphatidylcholine (36:2), is a neutral helper phospholipid which can be used in gene and drug delivery liposomal formulations. DOPC has been proven to promote more stable laminar structures. The helper lipids have been shown to improve the transfection efficiency in a variety of cell types when used in combination with charged lipids. At […]