The Multifunctional Nanocomposite of Poly(l-Lactide) and Polyethylene Glycol-Grafted GQDs for Enhanced Therapeutics and Molecule Analysis

Due to the large surface area and excellent mechanical flexibility, Photoluminescent (PL) graphene quantum dots (GQDs) with fascinating optical and electronic properties have promising applications in biomedical engineering. In order to enhance the therapeutic efficiency, the research team proposed a multifunctional nanocomposite of poly(l-lactide) (PLA) and polyethylene glycol (PEG)-grafted GQDs (f-GQDs) used for the analysis of intracellular […]

Mitomycin C and Methotrexate Loaded DSPE-PEG Micelles: A Key Factor for Nanoscale Drug Delivery System

The design of nanoscale drug delivery systems used for the targeted co-delivery of multiple therapeutic drugs still remains a challenge. However, researchers prepared mitomycin C (MMC) and methotrexate (MTX) loaded DSPE-PEG micelles (MTX-M-MMC) by self-assembly using the dialysis technique, and the MMC-soybean phosphatidylcholine complex was encapsulated in the MTX-functionalized DSPE-PEG micelles. The experiment suggested that MTX-M-MMC coordinate the early […]

The Roles the Diverse Phosphatidic Acid Species Play on Exocytoses

Phosphatidic Acid (PA) has aroused people’s interests due to its role in diverse key biological functions, including its being an intermediate in the synthesis of all membrane glycerophospholipids, a participant of membrane biogenesis, a necessary signaling molecule in cell proliferation and cytoskeletal rearrangement, as well as a participant in endocrine, neuroendocrine exocytosis and synaptic neurotransmission. Mammals can have more than […]

The Effect of PZLY on Hierarchy and Mechanics in Peptide-Polymer Hybirds

By combining the hierarchy of biological species with synthetic concepts, peptide-polymer hybrids can control the molecular design and material properties. By further incorporating covalent cross links, the molecular complexity is enhanced so that both a physical and covalent network is allowed. Through the process, both the structure and function of polyethylene glycol (PEG)-network hybrids are regulated by […]

1,2-Dimyristoyl-sn-glycero-3-phosphocholine (DMPC)

DMPC (1,2-ditetradecanoyl-sn-glycero-3-phosphocholine) is composed of saturated and symmetric phospholipids with 14 carbon atoms. As a zwitterionic phospholipids, DMPC can be used in the formulation of liposomes, lipid nanoparticles, and other related nanodelivery systems for gene delivery. Also, DMPC can be used for delivery of siRNA, mRNA, and plasmid DNA through the combination with cationic lipids. Furthermore, DMPC can […]

The Application of RGD@Micelles on Gastric Cancer Therapy

The polymer-drug conjugate with controlled drug release, such as arginine-glycine-aspartic acid (RGD)-decorated polyethylene glycol (PEG)-paclitaxel (PTX) conjugates containing disulfide linkage, can be used for gastric cancer therapy. The amphiphilic PEG-PTX conjugates can assemble into micelles, RGD@Micelles, and then decompose under the reduction of glutathione (GSH) and finally release PTX in weakly acidic conditions in intracellular environment. The […]

The Synthesis of Poly(2-ethyl-2-oxazoline) (PEOz)

Definition PEOz (Poly(2-ethyl-2-oxazoline)) is a hydrophilic long-chain polymer synthesized by living cationic ring-opening isomerization polymerization of 2-ethyl-2-oxazoline with the characteristics of low toxicity, biocompatibility, flexible chain and easy to modify. As a potential PEG substitute, it has similar hydrophilic and compliant properties to PEG. The synthesis of PEOz is simple and controllable, and its structure is easy to functionalized without hindering […]

Fluorescent Labeling Nanomedicine – A Promising System Used for Human Therapuetics

Nanomedicine is one of the most popular topics in disease diagnostics, prevention and treatment. Lipids, such as liposomes and solid lipid nanoparticles (SLNPs), are widely used in nanosystems, and these nanosystems are used for a variety of therapeutic fields, such as anticancer therapies, antimicrobials, treatment of central nervous system diseases and other conditions. By loading […]

The Introduction of Pd@Pt-PEG-Ce6: A Promising Platform for Enhanced Photodynamic Therapy

Photodynamic therapy (PDT) is able to kill cancer cells using reactive oxygen species, and it has a wide application in cancer treatment. However, its efficiency can be severely restricted by the hypoxic nature of most solid tumors and also can be reduced by the hydrophobicity and limited tumor selectivity of some photosensitizers. To overcome the limitations, the […]

1,2-didodecanoyl-sn-glycero-3-phosphocholine (DLPC)

DLPC (1,2-didodecanoyl-sn-glycero-3-phosphocholine), the dilauroyl diester of phosphatidiylcholine, is one of the most common cell membrane lipids. It can be used as a phospholipid standard to quantify phosphatidylcholine by electrospray ionization mass spectrometry. Properties: Molecular Formula: C32H64NO8P Percent Composition: C 61.81%, H 10.37%, N 2.25%, O 20.58%, P 4.98% Form: White powder Purity: 99% Stability: 2 Years Solubility: 25 […]

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