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The Promise of PEI (Polyetherimide) in Drug Delivery

Definition PEI (Polyetherimide) is an amorphous amber-to-transparent engineering thermoplastic. The molecular formula of PEI is C37H24O6N2. Owing to its high temperature resistance and tensile strength, dimensional stability, excellent flame resistance and low smoke emission, PEI has been an ideal material used in the automotive, electrical, medical and other industrial fields. It is also a promising […]

PAMAM (Poly(amidoamine)) Dendrimer: A Promising Tool in Drug Delivery

Definition PAMAM (Poly(amidoamine)), a class of dendrimer with spherical shape composed of repeatedly branched subunits of amide and amine functionality, is characterized by an internal molecular structure of tree-like branches, with each outward layer containing exponentially more branching points. PAMAM has good molecular uniformity, narrow distribution of molecular weight, defined size and shape characteristics, as well as a multifunctional […]

The Synthesis of Poly(2-ethyl-2-oxazoline) (PEOz)

Definition PEOz (Poly(2-ethyl-2-oxazoline)) is a hydrophilic long-chain polymer synthesized by living cationic ring-opening isomerization polymerization of 2-ethyl-2-oxazoline with the characteristics of low toxicity, biocompatibility, flexible chain and easy to modify. As a potential PEG substitute, it has similar hydrophilic and compliant properties to PEG. The synthesis of PEOz is simple and controllable, and its structure is easy to functionalized without hindering […]

Brief Introduction of PEGylation

Definition: PEGylation is a process of both covalent and non-covalent attachment or consolidation of polyethylene glycol (PEG) polymer chains to molecules and macrostructures, such as drugs, therapeutic proteins or vesicles. As a biocompatible and hydrophilic polymer, PEG can be covalently linked to a variety of molecules to improve their pharmacokinetics and therapeutic properties. PEGylation affects the resulting derivatives […]

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