DEL for Protein-Protein Interaction

Protein-protein interactions (PPI) are physical and chemical contacts between two or more protein molecules. As a fundamental aspect of almost all biological processes, any interference of the sophisticated PPI network could result in potential physiological disorder or disease. Although some PPI networks have been well-established for their roles in tumor development and therefore have been […]

DNA-Encoded Library (DEL) for Compound Optimization & Expansion

DNA-encoded library (DEL) technology represents a revolutionary method in drug discovery. Unlike conventional approaches, DEL enables unparalleled exploration of chemical space, leading to the rapid identification of novel potent compounds. Although the importance of DEL screening in hit discovery has been well recognized, the power of DEL technology in compound optimization has only been appreciated […]

DEL for Covalent Ligand Discovery

Although many covalent drugs were serendipitously discovered historically, covalent inhibitors were in general discouraged due to the concerns over their interference with biological assays and potential lack of selectivity. Over the past decades, rational design of covalent inhibitors has gained traction and garnered increased interest, particularly due to their stronger potency, prolonged target engagement, increased […]

DEL for Unconventional Applications

The advancement of DNA Encoded Library (DEL) technology has been significant in recent decades. Beyond its conventional role in small molecule drug discovery, its integration into emerging fields has begun to garner increased interest. This can be attributed to its large chemical space, abundant Structure-Signal Relationship (SSR) data, and inherent DNA conjugation properties. In this […]

Vernalis announces a drug discovery collaboration with C4X Discovery in inflammatory disease

Vernalis (R&D) Limited (“Vernalis”), a wholly owned subsidiary of HitGen Inc., and C4X Discovery (“C4XD”) are pleased to announce a collaboration to identify modulators of an undisclosed high-value target involved in inflammatory disease. Within the collaboration, Vernalis will use its state-of-the-art protein science and Hit ID platforms to produce the target protein and to identify […]

Current update on nanoplatforms as therapeutic and diagnostic tools: A review for the materials used as nanotheranostics and imaging modalities

In the last decade, the use of nanotheranostics as emerging diagnostic and therapeutic tools for various diseases, especially cancer, is held great attention. Up to date, several approaches have been employed in order to develop smart nanotheranostics, which combine bioactive targeting on specific tissues as well as diagnostic properties. The nanotheranostics can deliver therapeutic agents […]

Alfa Chemistry Releases Functional PEGs for Biological and Therapeutic Research

The compounds conjugated with PEG (functional PEGs) have many advantages. Ever since its discovery, PEGylation is of increasing interest in biological and medical studies owing to their solubility in water, excellent biocompatibility and non-immunogenicity. The US-based chemical supplier Alfa Chemistry announces in a recent statement that it starts to provide functional PEGs for scientific research. Polyethylene glycol […]

A New Polyethylene Glycol Hydrogel (PEG-H) Model for Acute Bacterial Rhinosinusitis Treatment

Systemic antibiotic therapy is the major therapeutic method for acute bacterial rhinosinusitis (ABRS). However, this kind of therapy often gives rise to the side effects, such as dizziness, diarrhea and drug resistance. In order to avoid the side effects and achieve sustained release of drugs, researchers developed a new polyethylene glycol hydrogel (PEG-H) treatment model. […]

The Prevention of Bone Infections By Immobilizing Antibiotic-Loaded Polymeric Coatings on Orthopaedic Implants

In orthopaedic surgeries, the implant-associated infections are extremely critical as they may hinder bone healing, resulting in implant failure and even osteomyelitis. Used for local delivery of antibiotics at surgical sites, drug-eluting implants are considered to be a promising tool in infection prevention. The antibiotic vancomycin was encapsulated in a polyethylene glycol (PEG)-based hydrogel film which […]

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