α-Bromo-1,2-benzisoxazole-3-acetic Acid-13C2

Chemical Name:α-Bromo-1,2-benzisoxazole-3-acetic Acid-13C2
Synonyms:2-(1,2-Benzoxazol-3-yl)-2-bromoacetic Acid-13C2
Alternate CAS #:37924-67-7
Molecular Formula:C₇¹³C₂H₆BrNO₃
Molecular Weight:258.04
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:α-Bromo-1,2-benzisoxazole-3-acetic Acid-13C2 is an intermediate in the synthesis of Zonisamide-13C2-15N (Z700003) which is the labeled analogue of Zonisamide (Z700000), a sulfonamide antiseizure agent; blocks repetitive firing of voltagesensitive sodium channels and reduces voltage-sensitive T-type calcium currents. Heterocyclic methanesulfonide with anticonvulsant properties. The compound is under investigation for potential therapeutic use as an antiepileptic drug. Anticonvulsant.
References:Masuda, Y., et al.: Arzneim.-Forsch., 30, 477 (1980); Hammond, E.J., et al.: Gen. Pharmacol., 18, 303 (1987); Schmidt, D., et al.: Epilepsy Res., 15, 67 (1993); Sorkin, E.M., et al.: Drugs, 45, 760 (1993)
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