1-[4-(4-Ethoxyphenyl)thiazol-2-yl]-guanidine Hydrobromide

Chemical Name:1-[4-(4-Ethoxyphenyl)thiazol-2-yl]-guanidine Hydrobromide
Synonyms:N-[4-(4-Ethoxyphenyl)-2-thiazolyl]guanidine Hydrobromide; N-[4-(4-Ethoxyphenyl)-2-thiazolyl]guanidine Monohydrobromide;
Molecular Formula:C₁₂H₁₄N₄OS • HBr
Molecular Weight:262.33 + (80.91)
Category:Building Blocks;
Applications:1-[4-(4-Ethoxyphenyl)thiazol-2-yl]-guanidine Hydrobromide is related to 1-(4-(4-Methoxyphenyl)thiazol-2-yl)guanidine Hydrobromide (M226305), which is used in the preparation of antiulcer agents, specifically 4-Substituted 2-guanidinothiazoles, which are reversible, competitive, and selective inhibitors of gastric H+,K+-ATPase. 1-(4-(4-Methoxyphenyl)thiazol-2-yl)guanidine Hydrobromide is also used in the preparation of thiazole compounds as myosin light chain phosphatase inhibitors for prostate cancer treatment.
References:LaMattina, J., et al.: J. Med. Chem., 33, 543 (1990); Brown, M., Grindrod, S.: PCT Int. Appl. (2009), WO 2009146013 A1 20091203;
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