1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine-d4

Chemical Name:1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine-d4
Synonyms:9-Octadecenoic acid (9Z)-1,1′-[(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl] ester-d4;9-Octadecenoic acid (9Z)-(1R)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester-d4; (R)-9-Octadecenoic acid (Z)-1-[[[(2-aminoethoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester-d4; L-Olein 1,2-di-2-Aminoethyl Hydrogen Phosphate-d4; L-2-Amino-ethanol Dihydrogen Phosphate Monoester with 1,2-Diolein-d4; 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine-d4; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-d4; 1,2-Dioleoyl-sn-glycero-3-phosphorylethanolamine-d4; Coatsome MC 8181-d4; Coatsome ME 8181-d4; DOPE-d4; Dioleoyl-L-α-phosphatidylethanolamine-d4; Dioleoylphosphatidylethanolamine-d4; L-α-Dioleoylphosphatidylethanolamine-d4
Alternate CAS #:4004-05-1 Unlabelled
Molecular Formula:C₄₁H₇₄D₄NO₈P
Molecular Weight:748.06
Category:Research Tools;
Applications:1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine-d4 is labelled 1,2-Dioleoyl-sn-glycero-3-phosphatidylethanolamine (DOPE) (D482210) which is a synthetic analog of naturally-occurring PE containing 18:1 fatty acids at the sn-1 and sn-2 positions. DOPE can be used as an emulsifier to facilitate DNA-liposome complex transport across membranes. It is used in combination with cationic phospholipids to increase efficiency during DNA transfection studies as a non-viral method of gene delivery.
References:Misra, S.K., et al.: PLoS One, 8, e68305 (2013); MacDonald, R., et al.: J. Pharm. Sci., 88, 896 (1999); Chen, Y., et al.: Int. J. Nanomedicine, 8, 1573 (2013)
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