12-Ethyl-8-((formyloxy)methyl)-9-oxo-7-propionyl Irinotecan Lactone

Chemical Name:12-Ethyl-8-((formyloxy)methyl)-9-oxo-7-propionyl Irinotecan Lactone
Synonyms:12-Ethyl-8-((formyloxy)methyl)-9-oxo-7-propionyl-9,11-dihydroindolizino[1,2-b]quinolin-2-yl [1,4′-bipiperidine]-1′-carboxylate;Indolizino[1,2-b]quinoline, [1,4′-bipiperidine]-1′-carboxylic Acid Derivative
CAS Number:143490-56-6
Molecular Formula:C₃₃H₃₈N₄O₆
Molecular Weight:586.69
Category:Building Blocks; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:12-Ethyl-8-((formyloxy)methyl)-9-oxo-7-propionyl Irinotecan Lactone is an intermediate in the synthesis of Irinotecan Lactone Impurity (I767520), A lactone impurity of Irinotecan (I767500), a DNA topoisomerase inhibitor. A photodegradation product of a camptothecin derivative used as an anticancer drug.
References:Akimoto, K. et al.: J. Chrom. 734, 401 (1996); Kunimoto, T., et al.: Cancer Res., 47, 5944 (1987); Shimada, Y., et al.: J. Clin. Oncol., 11, 909 (1993); Chen, A., et al.: Annu. Rev. Pharmacol. Toxicol., 34, 191 (1994);
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