(16Alpha)?-17,20-Epoxy-16-methyl(d3)-20-[(trimethylsilyl)oxy]-pregna-1,4,9(11)-trien-3-one

Chemical Name:(16Alpha)?-17,20-Epoxy-16-methyl(d3)-20-[(trimethylsilyl)oxy]-pregna-1,4,9(11)-trien-3-one
Synonyms:(8S,10S,13S,14S,16R)-3′,10,13,16-Tetramethyl-3′-((trimethylsilyl)oxy)-7,8,10,12,13,14,15,16-octahydrospiro[cyclopenta[a]phenanthrene-17,2′-oxiran]-3(6H)-one-D3
Molecular Formula:C₂₅H₃₃D₃O₃Si
Molecular Weight:415.66
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites; Steroids;
Applications:(16α)​-17,20-Epoxy-16-methyl(d3)-20-[(trimethylsilyl)oxy]-pregna-1,4,9(11)-trien-3-one is an intermediate in the synthesis of Dexamethasone-d3 (D298803) is the labelled form of Dexamethasone (D298800), which is a glucocorticoid used as an anti-inflammatory agent. Dexamethasone regulates T-cell survival, growth, and differentiation. Dexamethasone inhibits the induction of nitric oxide synthase.
References:Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995), Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999), Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)
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