2-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)-4-(hydroxymethyl)cyclopentanol (Mixture of Diastereomers)

Chemical Name:2-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)-4-(hydroxymethyl)cyclopentanol (Mixture of Diastereomers)
Synonyms:Abacavir Impurity 3;
Impurity
Abacavir Impurity 3
CAS Number:2514723-87-4
Molecular Formula:C₁₄H₂₀N₆O₂
Molecular Weight:304.35
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-(2-Amino-6-(cyclopropylamino)-9H-purin-9-yl)-4-(hydroxymethyl)cyclopentanol is an impurity of Abacavir (A105000), Abacavir Sulfate (Abacavir – In House Impurity) is a carbocyclic 2′-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection. Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA. (Abacavir Impurity 3)
References:Jackson, A., et al.: Antivir Ther. 17, 19 (2012); Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)
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