2-[[5-Bromo-4-(5-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic Acid

Chemical Name:2-[[5-Bromo-4-(5-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic Acid
Synonyms:2-[[5-Bromo-4-(5-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl]thio]-acetic Acid
CAS Number:1533519-97-9
Molecular Formula:C₁₇H₁₄BrN₃O₂S
Molecular Weight:404.28
Category:Research Tools; Standards; Molecular Biology; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:2-[[5-Bromo-4-(5-cyclopropyl-1-naphthalenyl)-4H-1,2,4-triazol-3-yl]thio]-acetic Acid is an impurity of drug Lesinurad (L329700), which is used to synthesize febuxostat which is a non-purine analog inhibitor of xanthine oxidase. Febuxostat is approved by the European Medicines Agency and the US Food and Drug Administration for treating gout.
References:Burns, C., et al.: Lancet 377, 165 (2011); Miner, J. et al.: PCT Int. Appl. WO 2011159732 A1 20111222 (2011); Crittenden, D. B. et al.: Clinical Investigation 1, 1563-1575 (2011)
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