(3α,5β,7β)-Cholane-3,7,24-triol-d5

Chemical Name:(3α,5β,7β)-Cholane-3,7,24-triol-d5
Synonyms:(3R,5S,7S,8R,9S,10S,13R,14S,17R)-17-((R)-5-Hydroxypentan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,7-diol-d5
Alternate CAS #:unlabelled: 130593-75-8
Molecular Formula:C₂₄H₃₇D₅O₃
Molecular Weight:383.62
Category:Building Blocks; Isotopic Labeled Analogues;
Applications:(3α,5β,7β)-Cholane-3,7,24-triol-d5 is the labeled analog of (3α,5β,7β)-Cholane-3,7,24-triol (C292530), which is used in the preparation of Ursodeoxycholic Acid (U850000) scaffold. Ursodeoxycholic Acid scaffold is used to generate novel and selective steroidal ligands for GP-BAR1, a promising pharmacology target for the treatment of steatohepatitis, type 2 diabetes, and obesity.
References:Sepe, V., et. al.: Sepe, V., et. al.: J. Med. Chem., 57, 7687 (2014)
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