3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine

Chemical Name:3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine
Synonyms:NBI 30775; R 121919; R 121919 (Neurocrine Biosciences Inc.);
CAS Number:195055-03-9
Molecular Formula:C₂₂H₃₂N₆
Molecular Weight:380.53
Category:Research Tools;
Applications:3-[6-(Dimethylamino)-4-methyl-3-pyridinyl]-2,5-dimethyl-N,N-dipropylpyrazolo[1,5-a]pyrimidin-7-amine, is a potent and Orally active Corticotropin-Releasing factor 1 receptor antagonists, which is hown to reduce negative emotional symptoms of acute and protracted alcohol withdrawal, and thus used for the treatment of alcoholism.
References:Takahashi, Y., et al.: J. Med. Chem., 55, 8450 (2012); Zorrilla, E., Drug and Alcohol Dependence, 128, 175 (2013);
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