3-Hydroxy-3,3′,5′-triiodo-thyroxine (Mixture of Diastereomers)

Chemical Name:3-Hydroxy-3,3′,5′-triiodo-thyroxine (Mixture of Diastereomers)
Synonyms:2-Amino-3-hydroxy-3-(4-(4-hydroxy-3,5-diodophenoxy)-3-iodophenyl)propanioc Acid; Beta-Hydroxy T3 Impurity;
Molecular Formula:C₁₅H₁₂I₃NO₅
Molecular Weight:666.97
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-Hydroxy-3,3′,5′-triiodo-thyroxine (Mixture of Diastereomers) is a derivative compound of Thyroxine (H97750). Thyroxine is one of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
References:Post, A., et al.: Anal. Profiles Drug Subs., 5, 225 (1976), Nelson, J.C., et al.: Clin. Chem., 34, 1737 (1988), Fischer, D.A., et al.: Clin. Chem., 42, 135 (1996), Cavalieri, R.R., et al.: Thyroid, 7, 177 (1997),
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