4-Defluoro-4-(p-fluorophenyl)aprepitant-13C, 15N2

Chemical Name:4-Defluoro-4-(p-fluorophenyl)aprepitant-13C, 15N2
Synonyms:3-(((2R,3S)-2-((R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy)-3-(4′-fluoro-[1,1′-biphenyl]-4-yl)morpholino)methyl)-1H-1,2,4-triazol-5(4H)-one-13C, 15N2
Alternate CAS #:Unlabelled CAS# N/A
Molecular Formula:C₂₈¹³CH₂₅F₇N₂¹⁵N₂O₃
Molecular Weight:613.5
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-Defluoro-4-(p-fluorophenyl)aprepitant-13C, 15N2 is the labeled analogue of 4-Defluoro-4-(p-fluorophenyl)aprepitant (D228722), an impurity of Aprepitant (A729800), a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
References:Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002); Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)
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