4-Epianhydrodemeclocycline

Chemical Name:4-Epianhydrodemeclocycline
Synonyms:2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-1,12-dioxo-, [4R-(4α,4aβ,12aβ)]- (9CI); (4R,4aS,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-1,12-dioxo-2-naphthacenecarboxamide; 4-Epianhydrodemethylchlortetracycline; Epianhydrodemethylchlortetracycline
CAS Number:81181-91-1
Molecular Formula:C₂₁H₁₉ClN₂O₇
Molecular Weight:446.84
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics;
Applications:4-Epianhydrodemeclocycline is an impurity of Demeclocycline (D230725), an antibiotic related to tetracycline and produced by streptomyces aureofaciens. Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
References:Jilka, R., et al.: J. Clin. Invest., 104, 439 (1999), Hauge, E; Bone, 28, 556 (2001), Dobnig, H., et al.: J. Clin. Endocrinol. Metab., 90, 3970 (2005),
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