4-Hydroxy-3-(hydroxymethyl)benzaldehyde

Chemical Name:4-Hydroxy-3-(hydroxymethyl)benzaldehyde
Synonyms:3-(Hydroxymethyl)-4-hydroxybenzaldehyde; Salbutamol Impurity Q;
CAS Number:54030-32-9
Molecular Formula:C₈H₈O₃
Molecular Weight:152.15
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:4-Hydroxy-3-(hydroxymethyl)benzaldehyde is an impurity of Albuterol (A514501) which is a β2-adrenoceptor agonist, a bronchodilator and a tocolytic. 4-Hydroxy-3-(hydroxymethyl)benzaldehyde is also used in the preparation of Cinnamyl alcohol-like compounds which can be used for treatment of free radical generated related diseases inlcuding auto-immunodeficiency diseases. It is also used as a reagent in the synthesis of 5-Diacetoxymethyl-cycloSal-d4TMP which is a prototype of enzymatically activated cycloSal-pronucleotides that may possess antiviral activities against HIV.
References:Zhao, Y., et al.:  Cinnamyl alcohol-like compounds, their preparation method and application, China Patent 101092336 Dec 26, 2007; Gisch, N., et al.: Nucleos. Nucleot. Nucl., 26, 861 (2007); Miyagawa, N., et al.: Biol. Pharm. Bull., 31, 2260 (2008), Gonzalez-Munoz, C., et al.: Eur. J. Pharmacol., 607, 151 (2009), Kern, C., et al.: J. Med. Chem., 52, 1773 (2009),
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