4-Hydroxy-PAC 1-β-D-Glucopyranosiduronic Acid-d8

Chemical Name:4-Hydroxy-PAC 1-β-D-Glucopyranosiduronic Acid-d8
Synonyms:(2S,3S,4S,5R,6S)-6-(2-Allyl-4-((E)-(2-(2-(4-benzylpiperazin-1-yl)acetyl)hydrazono)methyl)-3-hydroxyphenoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic Acid-d8;
Molecular Formula:C₂₉H₂₈D₈N₄O₉
Molecular Weight:592.67
Category:Standards; Isotopic Labeled Analogues;
Applications:4-Hydroxy-PAC 1-β-D-Glucopyranosiduronic Acid-d8 is deuterium labeled 4-Hydroxy-PAC 1-β-D-Glucopyranosiduronic Acid. 4-Hydroxy-PAC 1-β-D-Glucopyranosiduronic Acid is a metabolite of PAC-1 (P132000), which is a potential anti-tumor drug candidate that activates caspase 3 and induces apoptosis in both in vitro and in vivo against mice tumors. Metabolites and derivatives of PAC-1 are useful compounds to investigate the mechanism of action and to serve as standards (ie. LC/MS).
References:Ren, L., et al.: J. Chromatogr. B (2008); Slee, E., et al.: J. Biol. Chem., 276, 7320 (2001); Pop, C., et al.: Biochemistry, 42, 12311 (2003); Li, L., et al.: Science, 305, 1471 (2004); Green, D., et al.: J. Clin. Invest., 115, 2610 (2005); Satoh, T., et al.: Clin. Cancer Res., 15, 3872 (2009)
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