5-[5-(1,1-Dimethylethyl)-2,4-dihydroxyphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide

Chemical Name:5-[5-(1,1-Dimethylethyl)-2,4-dihydroxyphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide
Synonyms:AUY922;
CAS Number:747412-64-2
Molecular Formula:C₂₇H₃₃N₃O₅
Molecular Weight:479.57
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:5-[5-(1,1-Dimethylethyl)-2,4-dihydroxyphenyl]-N-ethyl-4-[4-(4-morpholinylmethyl)phenyl]-3-isoxazolecarboxamide is a Hsp90 inhibitor that be useful in the treatment of multiple myeloma and breast cancer.
References:Swuec, P., et al.: Bioorg. Med. Chem., 20, 408 (2012); Giaccone, G., et al.: Cell Cycle, 8, 2682 (2009)
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