5-Carboxymethylaminomethyluridine

Chemical Name:5-Carboxymethylaminomethyluridine
Synonyms:cmnm5U;2-(((1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl)amino)acetic Acid;N-[(1,2,3,4-Tetrahydro-2,4-dioxo-1-β-D-ribofuranosyl-5-pyrimidinyl)methyl]glycine;5-Carboxymethylaminomethyluridine
CAS Number:69181-26-6
Molecular Formula:C₁₂H₁₇N₃O₈
Molecular Weight:331.28
Category:Research Tools; Standards; Molecular Biology; Nucleic Acids; Natural Products;
Applications:5-Carboxymethylaminomethyluridine or cmnm5U, is a modification of tRNA responsible for restricting codon-anticodon wobbling and recognition of purine-ending codons. This modification can be catalyzed by the action of GidA and MnmE enzymes on uridine.
References:Osawa, T., et. al.: Structure J., 17, 713 (2009);Takai, K, Yokoyama, S., Nucleic Acids Res., 31, 6383 (2003)
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