5-Hydroxy-6-methoxy Duloxetine N-Allyl Acetate

Chemical Name:5-Hydroxy-6-methoxy Duloxetine N-Allyl Acetate
Synonyms:Allyl (S)-(3-((5-Hydroxy-6-methoxynaphthalen-1-yl)oxy)-3-(thiophen-2-yl)propyl)(methyl)carbamate
Molecular Formula:C₂₃H₂₅NO₅S
Molecular Weight:427.52
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:5-Hydroxy-6-methoxy Duloxetine N-Allyl Acetate is an intermediate in the synthesis of 5-Hydroxy-6-methoxy Duloxetine Sulfate Sodium Salt (H946305) which is the major metabolite of Duloxetine, an antidepressant. A dual serotonin and norepinephrine reuptake inhibitor (SNRI). Used in treatment of stress urinary incontinence.
References:Sharma, A., et al.: J. Clin. Pharmacol., 40, 161 (2000), Lantz, R., et al.: Drug Metab. Dispos., 31, 1142 (2003), Kuo, F., et al.: Bioorg. Med. Chem. Lett., 14, 5233 (2004), Suri, A., et al.: Int. J. Clin. Pharm. Ther., 43, 78 (2005),Wong, D.T., et al.: Neuropsychopharmacology, 8, 23 (1993), Fuller, R.W., et al.: J. Pharmacol. Exp. Ther., 269, 132 (1994), Sharma, A., et al.: J. Clin. Pharmacol., 40, 161 (2000)
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