6α-Methyl-20(R)-hydroxy Prednisolone 21-Acetate-d5

Chemical Name:6α-Methyl-20(R)-hydroxy Prednisolone 21-Acetate-d5
Synonyms:(6α,11β,20R)-21-(Acetyloxy)-11,17,20-trihydroxy-6-methylpregna-1,4-dien-3-one-d5; Methylprednisolone Acetate EP Impurity A-d5
Alternate CAS #:Unlabelled: 93963-74-7
Molecular Formula:C₂₄H₂₉D₅O₆
Molecular Weight:423.55
Category:Standards; Isotopic Labeled Analogues; Pharmaceutical/API Drug Impurities/Metabolites; Steroids;
Applications:6α-Methyl-20(R)-hydroxy Prednisolone 21-Acetate-d5 is the isotope labelled analog of 6α-Methyl-20(R)-hydroxy Prednisolone 21-Acetate (M312955); a metabolite of 6α-Methyl Prednisolone (M325934) which is a glucocorticoid that displays anti-inflammatory and antioxidant properties and attenuates apoptosis in oligodendrocytes after injury. Also neuroprotective.
References:Hall, E.D., et al.: J. Neurosurg., 76, 13 (1992); Hommes, O.R., et al.: Mult. Scler., 1, 327 (1996); Bracken, M.B., et al.: J. Neurosurg., 89, 699 (1998); Dammers, J.W.H.H., et al.: Brit. Med. J., 319, 884 (1999)
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