7-​(1-​Boc-​4-​piperidyl)​-​2-​(4-​phenoxyphenyl)​pyrazolo[1,​5-​a]​pyrimidine-​3-​carbonitrile

Chemical Name:7-​(1-​Boc-​4-​piperidyl)​-​2-​(4-​phenoxyphenyl)​pyrazolo[1,​5-​a]​pyrimidine-​3-​carbonitrile
Synonyms:1-​Dimethylethyl 4-​[3-​cyano-​2-​(4-​phenoxyphenyl)​pyrazolo[1,​5-​a]​pyrimidin-​7-​yl]​-​1-​piperidinecarboxylic Acid;tert-Butyl 4-(3-cyano-2-(4-phenoxyphenyl)pyrazolo[1,5-a]pyrimidin-7-yl)piperidine-1-carboxylate
CAS Number:2190506-55-7
Molecular Formula:C₂₉H₂₉N₅O₃
Molecular Weight:495.57
Category:Building Blocks; Molecular Biology; Enzyme Activators and Inhibitors;
Applications:7-​(1-​Boc-​4-​piperidyl)​-​2-​(4-​phenoxyphenyl)​pyrazolo[1,​5-​a]​pyrimidine-​3-​carbonitrile is used as a reagent in the synthesis of Zanubrutinib (BGB-3111), a novel, potent, and selective covalent inhibitor of Bruton’s tyrosine kinase.
References:Guo, Y., et al.: J. Med. Chem. 62, 7923 (2019)
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