3-Des-(4-fluorophenyl) 3-(4-Fluorobiphen-3-yl) Aprepitant

Chemical Name:3-Des-(4-fluorophenyl) 3-(4-Fluorobiphen-3-yl) Aprepitant
Molecular Formula:C₂₉H₂₅F₇N₄O₃
Molecular Weight:610.52
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:3-Des-(4-fluorophenyl) 3-(4-Fluorobiphen-3-yl) is a derivative of Aprepitant (A729800), which is a novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E1. Antiemetic.
References:Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998), Campos, D., et al.: J. Clin. Oncol., 19, 1759 (2001), Van Belle, S., et al.: Cancer, 94, 3032 (2002), Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (2006)
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