CAS:1496551-72-4|Chloro Sofosbuvir Desphosphate

Catalogue Number:C382100
Chemical Name:Chloro Sofosbuvir Desphosphate
Synonyms:(2’R)-2′-Chloro-2′-deoxy-2′-methyl-uridine
CAS Number:1496551-72-4
Molecular Formula:C₁₀H₁₃ClN₂O₅
Molecular Weight:276.67
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites; Anti-virals/Anti-retrovirals;
Applications:Chloro Sofosbuvir Desphosphate is a possible metabolite of Sofosbuvir (P839640) which is a prodrug that is metabolized to the active antiviral agent 2′-deoxy-2′-α-fluoro-β-C-methyluridine-5′-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C.
References:Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)
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