CAS:1496552-51-2|Chloro Sofosbuvir

Catalogue Number:C382095
Chemical Name:Chloro Sofosbuvir
Synonyms:N-[[P(S),2’R]-2′-Chloro-2′-deoxy-2′-methyl-P-phenyl-5′-uridylyl]-L-alanine 1-Methylethyl Ester
CAS Number:1496552-51-2
Molecular Formula:C₂₂H₂₉ClN₃O₉P
Molecular Weight:545.91
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Chloro Sofosbuvir is an impurity of Sofosbuvir (P839640); a prodrug that is metabolized to the active antiviral agent 2′-deoxy-2′-α-fluoro-β-C-methyluridine-5′-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled Sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.
References:Lam, A.M.,et al.: Antimicrob. Agents. Chemotherapy., 56, 3359 (2012); Lam, A.M., et al.: J. Virol., 85, 12334 (2011); Sofia, M.J., et al.: J. Medn. Chem., 53, 7202 (2010)
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