N-Despropyl Macitentan-d4

Chemical Name:N-Despropyl Macitentan-d4
Synonyms:N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-sulfamide-d4
Alternate CAS #:1103522-45-7 unlabelled
Molecular Formula:C₁₆H₁₀D₄Br₂N₆O₄S
Molecular Weight:550.22
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:N-Despropyl-macitentan-d4 is an isotopic form of N-Despropyl-macitentan (D297305). N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH)
References:Atsmon, J., et al.: Clin. Pharmacokinet., 525, 685 (2013); Sidharta, P.N., et al.: Clin. Drug Invest. (2014)
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