CAS:103121-85-3|1-[[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium Chloride

Catalogue Number:A603160
Chemical Name:1-[[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium Chloride
Synonyms:(6R-trans)1-[(7-amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl]-1-methyl-Pyrrolidinium Hydroxide Inner Salt Monohydrochloride; USP Cefepime Related Compound E; Cefepime EP Impurity E; NMP-ACA
Impurity:Cefepime EP Impurity E
CAS Number:103121-85-3
Alternate CAS #
Free Base: 110026-16-9
Molecular Formula:C₁₃H₂₀ClN₃O₃S
Appearance:Off-White to Pale Beige Solid
Melting Point:>150°C (dec.)
Molecular Weight:333.83
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
Stability
Very Hygroscopic
Category:Standards; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:1-[[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium Chloride (Cefepime EP Impurity E) is an impurity in the synthesis of Cefepime (C242750), a semisynthetic, fourth generation cephalosporin antibiotic. Antibacterial.
References:Khan, N.J., et al.: Antimicrob. Agents Chemother., 26, 585 (1984), Naito, T., et al.: J. Antibiot., 39, 1092 (1986), Okamoto, M.P., et al.: Clin. Pharmacokinet., 25, 88 (1993),
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