CAS:209977-56-0|(r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4 -yl]propionic Acid Sesquihydrate

Catalogue Number:A603150
Chemical Name:(r,s)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4 -yl]propionic Acid Sesquihydrate
Synonyms:AMOA; α-Amino-3-(carboxymethoxy)-5-methyl-4-isoxazolepropanoic Acid Hydrate (2:3)
CAS Number:209977-56-0
Molecular Formula:C₉H₁₂N₂O₆•1.5H₂O
Appearance:White Crystalline Solid
Melting Point:230°C dec.
Molecular Weight:271.23
Storage:-20°C
Solubility:Hot Methanol, Water
Stability
Store in freezer at -20°C
Category:Standards; Amino Acids; Neurochemicals;
Applications:A selective inhibitor of [3H]-AMPA binding in rat brain membranes. AMOA shows little affinity for [3H]-kainate binding sites or other sites on the NMDA receptor-channel complex, as represented by binding of [3H]-CPP, [3H]-gly or [3H]-MK-801. AMOA also selectively antagonizes AMPA-induced responses in rat cortical wedge preparations relative to kainate-, quisqualate- and NMDA-induced responses.
References:Frandsden, A., et al.: J. Neurochem., 55, 1821 (1990), Krogsgaard-Larsen, P., et al.: J. Med. Chem., 34, 123 (1991), Berg, M., et al.: Acta Neuropathalogica, 81, 255 (1991)
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