CAS:1204818-19-8|(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride

Catalogue Number:A630750
Chemical Name:(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride
Synonyms:(?R)-?-Amino-2,4,5-trifluorobenzenebutanoic Acid Hydrochloride
CAS Number:1204818-19-8
Alternate CAS #
Free base: 936630-57-8
Molecular Formula:C₁₀H₁₀F₃NO₂ • HCl
Appearance:White to Off-White Solid
Melting Point:196 – 201C
Molecular Weight:233.19 + (36.46)
Storage:4°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Stability
Hygroscopic
Category:Building Blocks; Chiral Molecules; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride is an intermediate in the synthesis of the new antidiabetic drug Sitagliptine (S491000); a trizolopyrazine dipeptidyl peptidase IV inhibitor.
References:Tasnadi, G., et al.: Org. Biomol. Chem., 8, 793 (2010); Kim, D., et al.: J. Med. Chem. 48, 141 (2005); Ahren, B., et al.: Eur. J. Pharmacol. 521 164 (2005);
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