CAS:125995-03-1|Atorvastatin Lactone

Catalogue Number:A791780
Chemical Name:Atorvastatin Lactone
Synonyms:5-(4-Fluorophenyl)-2-(1-methylethyl)-N,4-diphenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide; Atorvastatin δ-Lactone; USP Atorvastatin Related Compound H; Atorvastatin EP Impurity H
Impurity:Atorvastatin EP Impurity H/ Atorvastatin Related Compound H
CAS Number:125995-03-1
Molecular Formula:C₃₃H₃₃FN₂O₄
Appearance:White to Light Yellow Solid
Melting Point:>90°C (dec.)
Molecular Weight:540.62
Storage:-20°C
Solubility:Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Atorvastatin Lactone (Atorvastatin EP Impurity H) is an intermediate of Atorvastatin, a inhibitor of MAP kinase and/or HMG-CoA reductase for the treatment of inflammation.
References:Boyd, R., et al.: J. Clin. Pharmacol., 40, 91, (2000), Bogman, K., et al.: Br. J. Pharmacol., 132, 1183 (2001), Backman, J., et al.: Clin. Pharmacol. Ther., 72, 685 (2002), Kalvass, J., et al.: Drug Metab. Dispos., 35, 455(2007),
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