CAS:1557267-42-1|Abivertinib

Catalogue Number:A794658
Chemical Name:Abivertinib
Synonyms:Avitinib; N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]phenyl)acrylamide; -[3-[[2-[[3-Fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-2-propenamide; AC 0010;
CAS Number:1557267-42-1
Molecular Formula:C₂₆H₂₆FN₇O₂
Molecular Weight:478.53
Category:Standards; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Abivertinib is a pyrrolopyrimidine-based, irreversible inhibitor of the epidermal growth factor receptor (EGFR). Abivertinib synergistically strengthens anti-leukemia activity of venetoclax in acute myeloid leukemia in BTK-dependent manner.
References:Xia, Z., et al.: Eur. J. Med. Chem., 224, 113711 (2021); Huang, S., et al.: Mol. Oncol., 14, 2560 (2020)
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