CAS:848141-11-7|Avelestat

Catalogue Number:A794660
Chemical Name:Avelestat
Synonyms:1,2-dihydro-6-methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)-2-pyridinyl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-3-Pyridinecarboxamide; 6-Methyl-5-(1-methyl-1H-pyrazol-5-yl)-N-[[5-(methylsulfonyl)pyridin-2-yl]methyl]-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2-dihydropyridine-3-carboxamide; AZD9668; Alvelestat
CAS Number:848141-11-7
Molecular Formula:C₂₅H₂₂F₃N₅O₄S
Appearance:White to Off-White Solid
Melting Point:207-209°C
Molecular Weight:545.53
Storage:-20°C
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Research Tools; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Avelstat inhibits plasma neutrophil elastase (NE) activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.
References:Stevens, T., et al.: J. Pharmacol. Exp. Ther., 339, 313 (2011)
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