CAS:196309-76-9|BAY 11-7085

Catalogue Number:B118795
Chemical Name:BAY 11-7085
Synonyms:(2E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile; (E)-3-[[4-(1,1-Dimethylethyl)phenyl]sulfonyl]-2-propenenitrile; BAY 117083
CAS Number:196309-76-9
Molecular Formula:C₁₃H₁₅NO₂S
Appearance:White to Off-White Solid
Melting Point:83-86°C
Molecular Weight:249.33
Storage:4°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors;
Applications:BAY 11-7085 is a NF-κB (nuclear factor-κB) inhibitor and can be used as a therapeutic agent for the treatment of endometriosis. BAY 11-7085 inhibits the cell proliferation and DNA synthesis of endometriotic cyst stromal cells (ECSCs) and induces apoptosis by surpressing antiapoptotic proteins.
References:Berger, N., et al.: Exp. Hematol., 35, 1495 (2007); Nasu, K., et al.: Am. J. Physiol., 293, E16 (2007)
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