CAS:19542-67-7|BAY 11-7082

Catalogue Number:B118790
Chemical Name:BAY 11-7082
Synonyms:(2E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile; (E)-3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile; (E)-3-(p-Tolylsulfonyl)-acrylonitrile; BAY 11-7821; BAY 117821
CAS Number:19542-67-7
Molecular Formula:C₁₀H₉NO₂S
Appearance:Off-White Solid
Melting Point:129-131°C
Molecular Weight:207.25
Storage:-20°C
Solubility:Chloroform (Slightly), Methanol (Slightly)
Category:Standards; Enzyme Activators and Inhibitors;
Applications:BAY 11-7082 is a nuclear factor-κB (NF-κB) inhibitor and a potential anti-inflammatory agent. It selectively and irreversibly inhibits NF-κB activation by blocking TNF-a-induced phosphorylation of Iκba without affecting constitutive Iκba phosphorylation. Potent IKK inhibitor
References:Pierce, J.W., et al.: J. Biol. Chem., 272, 21096 (1997); Keller, S.A., et al.: Blood, 96, 2537 (2000); Remacle-Bonnet, M.M., et al.: Cancer Res., 60, 2007 (2000); Thévenod, F., et al.: J. Biol. Chem., 275, 1887 (2000); Petegnief, V., et al.: Neuroscience, 104, 223 (2001); Kauppinen, T.M., et al.: J. Immunol., 174, 2288 (2005)
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