CAS:1486471-13-9|Belinostat Glucuronide

Catalogue Number:B131405
Chemical Name:Belinostat Glucuronide
Synonyms:(2S,3S,4S,5R,6S)-3,4,5-Trihydroxy-6-(((E)-3-(3-(N-phenylsulfamoyl)phenyl)acrylamido)oxy)tetrahydro-2H-pyran-2-carboxylic Acid
CAS Number:1486471-13-9
Molecular Formula:C₂₁H₂₂N₂O₁₀S
Appearance:White to Off-White Solid
Melting Point:135 – 140°C
Molecular Weight:494.47
Storage:-20°C, Hygroscopic
Solubility:DMSO (Slightly), Methanol (Slightly)
Category:Standards; Chiral Molecules; Enzyme Activators and Inhibitors; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Belinostat Glucuronide is the major metabolite of Belinostat. Belinostat (B131400) is a novel histone deacetylase 3 selective inhibitor, which protects the b cells from cytokine-induced apoptosis.
References:Wang, L., et al.: PLoS One, 8, 54522 (2013); Chou, D.H., et al.: Chem. Biol., 19, 669 (2012); Hwang, J.J., et al.: Inves. New. Drugs., 30, 1434 (2012); Dizon, D.S., et al.: Gynecol. Oncol., 125, 367 (2012);
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