(S)-7-Benzyloxy Warfarin

Chemical Name:(S)-7-Benzyloxy Warfarin
Synonyms:(S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-7-(phenylmethoxy)-2H-1-benzopyran-2-one; (S)-3-(α-Acetonylbenzyl)-7-(benzyloxy)-4-hydroxy-coumarin; (S)-7-(Benzyloxy)-4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-chromen-2-one
Molecular Formula:C₂₆H₂₂O₅
Molecular Weight:414.45
Category:Research Tools;
Applications:(S)-7-Benzyloxy Warfarin is an intermediate in the synthesis of (S)-7-Hydroxy Warfarin (H996126), the S-enantiomer of the 7-hydroxyl metabolite of Warfarin (W498500). (S)-7-Hydroxy Warfarin was present at levels 7-folds higher in chimeric mice with humanized liver (than that in controlled mice) following (S)-Warfarin metabolism.
References:Wong, Y.W.J. et al.: Pharm. Res., 6, 982 (1989); O’Reilly, R.A. et al.: Clin. Pharmacol. Ther., 51, 656 (1992); Inoue, T. et al: Drug Metab. Dispos. 36, 2429 (2008)
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