Benzyl (S)-4,4-Diethoxy-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate

Chemical Name:Benzyl (S)-4,4-Diethoxy-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate
Molecular Formula:C₂₄H₃₅N₃O₅S
Molecular Weight:477.62
Category:Building Blocks; Miscellaneous; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Benzyl (S)-4,4-Diethoxy-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)butanoate is an intermediate in the synthesis of 9-(Desmorpholinylethyl) 7,9-(1-Hydroxyethylene) Cobicistat (D296915), an impurity of Cobicistat (O849600), an HIV protease inhibitor and has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.
References:Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);
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