Chemical Name:Acalabrutinib Acetaldehyde
Synonyms:(S)-4-(8-Amino-3-(1-(3-oxobutanoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide
Alternate CAS #:1420477-60-6
Molecular Formula:C₂₆H₂₅N₇O₃
Molecular Weight:483.52
Category:Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications:Acalabrutinib Acetaldehyde is an impurity of Acalabrutinib (A115605). Acalabrutinib, is an experimental anti-cancer drug and a selective Bruton’s tyrosine kinase (BTK) inhibitor. This kinase transmits signals from B-cell Receptor (BCR), and thus any genetic BTK mutation causes B-Cell immunodeficiency. Therefore, BTK inhibitors targeting B-cell signaling has shown great promise for the treatment of chronic lymphocytic leukemia (CLL).
References:Byrd; et al. (2015). “Acalabrutinib (ACP-196) in Relapsed Chronic Lymphocytic Leukemia.”; “AstraZeneca to buy Acerta for blood cancer drug”. www.rsc.org. Chemistry World – Royal Society of Chemistry. Retrieved 24 December 2015.
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